The research article EFFECTS OF ENCAPSULATED PROPOLIS ON BLOOD GLYCEMIC CONTROL, LIPID METABOLISM, AND INSULIN RESISTANCE IN TYPE 2 DIABETES MELITUS RATS writen by Yangjing Li(from Zhejiang Univesity), examines the effects that ncapsulated propolis has on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus (T2DM) rats. (Propolis is a safe natural products which is a resinous hive material collected by honeybees from various plant sources. It is a popular folk medicine possessing a broad spectrum of biological activities, such as anticancer, antioxidant, and antiinflammatory)
In the method, the dependent variable is Male Sprague-Dawley rats of about 270~370g. The independent variable is Propolis, which was obtained from colonies of honeybees. During experimental session, male Sprague-Dawley rats were fed with a high-fat diet (HFD) and injected with low-dose STZ 4 times every 6 days to induce the animal emerge T2DM symptom. For the grouping part, T2DM rats were randomly assigned into 5 groups via fasting glucose and fasting body weight: model control group, low-, middle- and high-dose encapsulated propolis group, and positive control group. These 5 groups were continued on their HFD for the duration of the study.
The results show that at the beginning of drug administration, there were no differences in body weight. At the following 10 weeks period of drug administration, the body weight of each group increased gradually. Three weeks after drug administration, the body weight of model control group increased significantly than normal control group contemporary, and body weight of encapsulated propolis treated groups increased at equal pace with model control group; however, the body weight of T2DM rats treated with positive drug increased quicker than model control group, and had significant difference on 7th and 10th week of drug administration.
In conclusion, this research displays that encapsulated propolis exert multiple beneficial effects in fat-fed, streptozotocin-treated type 2 diabetes. Improvement of hyperglycemia and hyperlipidaemia is associated with a marked increase of insulin sensitivity. This study brings new light on innovational ways in treating type 2 diabetes. Further experiments are expected to gain more information and supports on clinical applications.
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